phytochemistry and biologic activities of caulerpa peltata native to oman sea

نویسندگان

nasrin movahhedin students’ research committee, tabriz university of medical sciences, tabriz, iran, research center for pharmaceutical nanotechnology, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran

jaleh barar research center for pharmaceutical nanotechnology, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran visiting assistant professor, ovarian cancer research center, school of medicine, university of pennsylvania, philadelphia, usa

fatemeh fathi azad faculty of pharmacy, tabriz university of medical sciences, tabriz, iran

abolfazl barzegari research center for pharmaceutical nanotechnology, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran

چکیده

general toxicity, antiproliferative, antibacterial and antioxidant activities of caulerpa peltata j.v.lamouroux (caulerpaceae) collected from oman sea were investigated. dried, ground alga was soxhlet-extracted with hexane, dichloromethane and methanol successively. the methanol extract was subjected to vacuum liquid chromatography (vlc) fractionation on silica gel using a step gradient of different mixture of solvents. a known alkaloid, caulerpin, was subsequently isolated from the fraction eluted by ethyl acatete100%. the antioxidant activity of all extracts was assessed by using the (dpph) assay. antiproliferative activity of the all extracts and caulerpin against the cancerous cell line was evaluated using mtt assay. general toxicity of extracts was determined using brine shrimp lethality assay (bsla). based on our results, a weak activity observed for all extracts in mtt assay, while they were toxic toward brine shrimp nauplii comparing to the podophylotoxin. this is the first report on phytochemistry and bioactivity of c.peltata which collected from oman sea.

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Phytochemistry and biologic activities of Caulerpa peltata native to Oman Sea

General toxicity, antiproliferative, antibacterial and antioxidant activities of Caulerpa peltata J.V.Lamouroux (Caulerpaceae) collected from Oman Sea were investigated. Dried, ground alga was Soxhlet-extracted with hexane, dichloromethane and methanol successively. The methanol extract was subjected to vacuum liquid chromatography (VLC) fractionation on silica gel using a step gradient of diff...

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Phytochemistry and biologic activities of Caulerpa peltata native to Oman Sea

General toxicity, antiproliferative, antibacterial and antioxidant activities of Caulerpa peltata J.V.Lamouroux (Caulerpaceae) collected from Oman Sea were investigated. Dried, ground alga was Soxhlet-extracted with hexane, dichloromethane and methanol successively. The methanol extract was subjected to vacuum liquid chromatography (VLC) fractionation on silica gel using a step gradient of diff...

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Phytochemistry and Biologic Activities of Caulerpa Peltata Native to Oman Sea

General toxicity, antiproliferative, antibacterial and antioxidant activities of Caulerpa peltata J.V.Lamouroux (Caulerpaceae) collected from Oman Sea were investigated. Dried, ground alga was Soxhlet-extracted with hexane, dichloromethane and methanol successively. The methanol extract was subjected to vacuum liquid chromatography (VLC) fractionation on silica gel using a step gradient of diff...

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عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۱۳، شماره ۲، صفحات ۵۱۵-۵۲۱

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